Background: Pakistan is currently facing the largest outbreak of ceftriaxone-resistant Salmonella enterica serotype Typhi described to date. Here we aimed to report the outbreak investigation done in Hyderabad, Pakistan, and identify disease risk factors. Methods: We did an age-matched case-control study, in which cases of ceftriaxone-resistant S Typhi were identified from active sentinal sites three hospitals in Hyderabad, Pakistan , community, and laboratory-based surveillance. Ceftriaxone-resistant S Typhi infection ie, resistance to ampicillin, chloramphenicol, co-trimoxazole, fluoroquinole, and ceftriaxone was confirmed using blood culture. Healthy participants controls were enrolled for the first people cases with ceftriaxone-resistant S Typhi. A structured questionnaire was administered to identify exposures 4 weeks before the illness cases or enrolment controls. Cases were included if written informed consent was provided. Four controls were selected from the same community as the corresponding case, matched on age, being healthy at the time of enrolment, and with no febrile illness in the 4 weeks before enrolment.
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Its history dates back to medieval times, when Ganjo Takker Barren Hill , a nearby hilly tract, was used as a place of worship. Lying on the most northern hill of the Ganjo Takker ridge, just east of the river Indus, it is the third largest city in the province and the eighth largest in the country with an expanse over three hillocks part of the most northerly hills of the Ganjo Takker range, 32 miles east of the Indus with which it is connected by various routes leading to Gidu Bandar.
Hyderabad, as the historic capital of Sindh, is the centre of all the provincial communications: road, rail, waterways and air. From the date of its foundation , its manufactures-ornamented silks, silver- and gold-work, and lacquered ware-have been the chief in the province, and during its heyday had gained prizes at the industrial exhibitions of Europe.
Some noteworthy antiquities are the tombs’ of the Kalhora jagirani and Talpur rulers.
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Opening Date ; Tender Notice For Selection Of Transportor For Pakistan Post Under The Postmaster General Northern Sindh Circle Hyderabad.
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From Wikimedia Commons, the free media repository. File information. Structured data. Captions English Add a one-line explanation of what this file represents. Summary [ edit ] Description Sindh Hyderabad Saddar city map. Arunreginald at en.
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Hyderabad is the second largest city of Sindh Province. The city was conquered by Mian Ghulam Shah Kalhoro upon the ruins of a Mauryan fishing village.
It is the second-largest city in Sindh and 8th largest in Pakistan. The city was named in honour of Ali ,  the fourth caliph and cousin of the Prophet Muhammad. The River Indus was changing course around , resulting in periodic floods of the then capital of the Kalhora dynasty , Khudabad. Mian Ghulam Shah Kalhoro decided to shift the capital away from Khudabad, and founded Hyderabad in over a limestone ridge on the eastern bank of the Indus River known as Ganjo Takkar , or “Bald Hill.
In , Mian Ghulam Shah Kalhoro ordered a fort to be built on one of the three hills of Hyderabad to house and defend his people. The fort was built using baked clay bricks, earning it the name Pacco Qillo , meaning Strong Fort in Sindhi. Hyderabad remained the Kalhora capital during the period in which Sindh was united under their rule. Attracted by the security of the city, Hyderabad began to attract artisans and traders from throughout Sindh, thereby resulting in the decline of other rival trading centres such as Khudabad.
Those groups retained the term “Khudabadi” in the names of their communities as a marker of origin. In , Sarfraz Khan built a “New” Khudabad north of Hala in memory of the old Kalhoro capital, and attempted to shift his capital there. He then captured Hyderabad in ,  and shifted his capital there in after Khudabad once again flooded. Renovation and reconstruction of the city’s fort began in , and lasted for 3 years. Talpur rule maintained Hyderabad’s security, and the city continued to attract migrants from throughout Sindh, turning the city into a major regional center.
Lohana Hindus from Afghanistan migrated to the city and set up ship as metalworkers.